Griffonia simplicifolia (5-HTP)
Griffonia simplicifolia is a woody climbing shrub native to West Africa and Central Africa. It grows to about 3 m, and bears greenish flowers followed by black pods.
Active Principle:
The seeds of the plant are used as a herbal supplement for their 5-Hydroxytryptophan content also known as 5-HTP.
5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally-occurring amino acid and chemical precursor as well as metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from tryptophan.
5-Hydroxytryptophan is decarboxylated to serotonin (5-hydroxytryptamine or 5-HT) by the enzyme aromatic-L-amino-acid decarboxylase with the help of Vitamin B6.
This reaction occurs both in nervous tissue and in the liver.5-HTP crosses the blood-brain barrier, while 5-HT does not. Excess 5-HTP, especially when administered with Vitamin B6, is thought to be metabolized and excreted.
Pharmacology
The psychoactive action of 5-HTP is derived from its effect on the production of serotonin in central nervous system tissue. More specifically, 5-HTP increases the production of serotonin. Thus, it has been used to treat diseases, e.g. depression, for which the lack of serotonin is thought to be a contributing factor.
Clinical Uses:
- 5- HTP provides the quickest, most effective, and most consistent overall results in treating insomnia.
- 5-HTP improves the quality of sleep and is also useful in the treatment of sleep disorders other than insomnia.
- 5-HTP makes sleep more restful and rejuvenating.
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Disclaimer : These claims have not been evaluated by the Food and Drug Administration. These products are not intended to cure, mitigate, treat or prevent any disease
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